Transcript: CDKN2B-AS1:30

Basic information

LNCipedia transcript ID: CDKN2B-AS1:30 
LNCipedia gene ID: CDKN2B-AS1
Location (hg38): chr9:22046281-22049250
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 581 bp
Exons: 3
Sources: NONCODE v4
Alternative transcript names: NONHSAT130431
Alternative gene names: ANRIL; CDKN2BAS; RP11-145E5.4; NCRNA00089; p15AS; CDKN2B-AS; PCAT12


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -226.9882 non-coding 
CPAT coding probability 0.32% non-coding 
Bazzini small ORFs 0 non-coding 

In stringent set: yes

Locus conservation

Locus conservation?
CDKN2B-AS1:30 no no no no

Available literature

  1. Aguilo (2016), Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease., Curr. Top. Microbiol. Immunol.
  2. Hu (2016), The plasma lncRNA acting as fingerprint in non-small-cell lung cancer., Tumour Biol.
  3. Iranpour (2016), Expression analysis of four long noncoding RNAs in breast cancer., Tumour Biol.
  4. Kotake (2016), Oncogenic Ras influences the expression of multiple lncRNAs., Cytotechnology
  5. Naemura (2016), ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture., Mol. Cell. Biochem.
  6. Zhou (2016), Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway., RNA Biol
  7. Bida (2015), A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel., Oncotarget
  8. Cabanski (2015), Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function., RNA Biol
  9. Carter (2015), Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus., BBA Clin
  10. Ding (2015), Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades., J. Exp. Clin. Cancer Res.
  11. Fan (2015), Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis., Genome Biol.
  12. Fan (2015), Erratum to: Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis., Genome Biol.
  13. Fiscon (2015), MONSTER v1.1: a tool to extract and search for RNA non-branching structures., BMC Genomics
  14. Hao (2015), Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma., BMC Cancer
  15. He (2015), LongTarget: a tool to predict lncRNA DNA-binding motifs and binding sites via Hoogsteen base-pairing analysis., Bioinformatics
  16. Holdt (2015), Long noncoding RNA-MicroRNA pathway controlling nuclear factor IA, a novel atherosclerosis modifier gene., Arterioscler. Thromb. Vasc. Biol.
  17. Hu (2015), β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression., Anticancer Drugs
  18. Hua (2015), High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma., Int J Clin Exp Pathol
  19. Huang (2015), Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2., J Hematol Oncol
  20. Kang (2015), Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer., Tumour Biol.
  21. Kang (2015), Down-regulation of Phospholipase D Stimulates Death of Lung Cancer Cells Involving Up-regulation of the Long ncRNA ANRIL., Anticancer Res.
  22. Kotake (2015), Transcriptional Regulation of the p16 Tumor Suppressor Gene., Anticancer Res.
  23. Kotake (2015), [Regulation of cell proliferation and apoptosis by long noncoding RNA, ANRIL and PANDA]., Seikagaku
  24. Li (2015), MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks., Drug Metab. Rev.
  25. Lin (2015), Increased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis., Diagn Pathol
  26. Lyu (2015), [Prediction of regulating network of innate immune signaling molecule hsa-miR-181a in stroke development based on bioinformatics analysis]., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
  27. Martínez-Fernández (2015), Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer., Clin Epigenetics
  28. Martínez-Fernández (2015), EZH2 in Bladder Cancer, a Promising Therapeutic Target., Int J Mol Sci
  29. Mirza (2015), Transcriptomic landscape of lncRNAs in inflammatory bowel disease., Genome Med
  30. Na (2015), Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway., Int J Clin Exp Med
  31. Naemura (2015), Long Noncoding RNA ANRIL Regulates Proliferation of Non-small Cell Lung Cancer and Cervical Cancer Cells., Anticancer Res.
  32. Nie (2015), Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression., Mol. Cancer Ther.
  33. Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
  34. Qiu (2015), Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer., Int. J. Oncol.
  35. Quek (2015), lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs., Nucleic Acids Res.
  36. Ren (2015), Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer., Int J Clin Exp Pathol
  37. Ruan (2015), Long non-coding RNA expression profile in atrial fibrillation., Int J Clin Exp Pathol
  38. Rupaimoole (2015), Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis., Cell Rep
  39. Smolle (2015), Long Non-Coding RNAs in Endometrial Carcinoma., Int J Mol Sci
  40. Sun (2015), Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma., Int J Clin Exp Pathol
  41. Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
  42. Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
  43. Wang (2015), Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival., Int J Clin Exp Pathol
  44. Wang (2015), Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma., PLoS ONE
  45. Wei (2015), Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor., Oncotarget
  46. Xie (2015), Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression., Oncotarget
  47. Yang (2015), Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457., Int J Clin Exp Pathol
  48. Ye (2015), Evaluation of four genetic variants in han chinese subjects with high myopia., J Ophthalmol
  49. Yu (2015), [Update on the role of LncRNA ANRIL at human chromosome 9p21 on the pathogenesis of atherosclerosis]., Zhonghua Xin Xue Guan Bing Za Zhi
  50. Zhai (2015), Long noncoding RNA MALAT1 as a putative biomarker of lymph node metastasis: a meta-analysis., Int J Clin Exp Med
  51. Zhang (2015), Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value., Biomed Res Int
  52. Zhang (2015), Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma., PLoS ONE
  53. Zhu (2015), Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway., Biochem. Biophys. Res. Commun.
  54. Bai (2014), Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke., Stroke
  55. Barnhill (2014), High expression of CAI2, a 9p21-embedded long noncoding RNA, contributes to advanced-stage neuroblastoma., Cancer Res.
  56. Bayoglu (2014), The severity of internal carotid artery stenosis is associated with the cyclin-dependent kinase inhibitor 2A gene expression., J. Atheroscler. Thromb.
  57. Chen (2014), ANRIL inhibits p15(INK4b) through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma., Cell. Immunol.
  58. Chen (2014), Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?, Curr Cardiol Rep
  59. Chen (2014), Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma., Med. Oncol.
  60. Cheng (2014), Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation., Front Genet
  61. Ding (2014), Expression of long non-coding RNA LOC285194 and its prognostic significance in human pancreatic ductal adenocarcinoma., Int J Clin Exp Pathol
  62. Dryden (2014), Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C., Genome Res.
  63. Emmrich (2014), LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia., Mol. Cancer
  64. Fadista (2014), Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism., Proc. Natl. Acad. Sci. U.S.A.
  65. Halley (2014), Regulation of the apolipoprotein gene cluster by a long noncoding RNA., Cell Rep
  66. Han (2014), LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition., BMC Cancer
  67. Hu (2014), A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer., Cancer Cell
  68. Huang (2014), Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis., Int J Mol Sci
  69. Kim (2014), The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3., BMC Med. Genet.
  70. Li (2014), A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β., Cancer Cell
  71. Liu (2014), Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases., Arterioscler. Thromb. Vasc. Biol.
  72. Ohms (2014), LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?, Front Genet
  73. Pestell (2014), Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo., Asian J. Androl.
  74. Roberts (2014), The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease., Philos. Trans. R. Soc. Lond., B, Biol. Sci.
  75. Skroblin (2014), "Going long": long non-coding RNAs as biomarkers., Circ. Res.
  76. Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
  77. Tani (2014), Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells., PLoS ONE
  78. Vausort (2014), Long noncoding RNAs in patients with acute myocardial infarction., Circ. Res.
  79. Vishal (2014), Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population., Sci Rep
  80. Wan (2014), Noncoding RNAs in DNA repair and genome integrity., Antioxid. Redox Signal.
  81. Yang (2014), A network based method for analysis of lncRNA-disease associations and prediction of lncRNAs implicated in diseases., PLoS ONE
  82. Yao (2014), Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas., Int J Clin Exp Pathol
  83. Zhang (2014), Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a., Oncotarget
  84. Ahmed (2013), Association of ANRIL polymorphism (rs1333049:C>G) with myocardial infarction and its pharmacogenomic role in hypercholesterolemia., Gene
  85. Bhartiya (2013), lncRNome: a comprehensive knowledgebase of human long noncoding RNAs., Database (Oxford)
  86. Bochenek (2013), The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10., Hum. Mol. Genet.
  87. Du (2013), Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer., Nat. Struct. Mol. Biol.
  88. He (2013), ANRIL/CDKN2B-AS shows two-stage clade-specific evolution and becomes conserved after transposon insertions in simians., BMC Evol. Biol.
  89. Holdt (2013), Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks., PLoS Genet.
  90. Johnson (2013), Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study., Circulation
  91. Kapusta (2013), Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs., PLoS Genet.
  92. Li (2013), Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer., J. Exp. Clin. Cancer Res.
  93. Lu (2013), Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression., BMC Cancer
  94. Ning (2013), A global map for dissecting phenotypic variants in human lincRNAs., Eur. J. Hum. Genet.
  95. Perkel (2013), Assume nothing: the tale of circular RNA., BioTechniques
  96. Qureshi (2013), Developing epigenetic diagnostics and therapeutics for brain disorders., Trends Mol Med
  97. Tang (2013), Long noncoding RNAs-related diseases, cancers, and drugs., ScientificWorldJournal
  98. Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
  99. Zhang (2013), Circular intronic long noncoding RNAs., Mol. Cell
  100. Özgür (2013), Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells., Clin. Exp. Med.
  101. Burdon (2012), Glaucoma risk alleles at CDKN2B-AS1 are associated with lower intraocular pressure, normal-tension glaucoma, and advanced glaucoma., Ophthalmology
  102. Congrains (2012), CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC., Biochem. Biophys. Res. Commun.
  103. Dereure (2012), [Role of non-coding RNA ANRIL in the genesis of plexiform neurofibromas in neurofibromatosis type 1]., Ann Dermatol Venereol
  104. Flockhart (2012), BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration., Genome Res.
  105. Foroud (2012), Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk., Stroke
  106. Martin (2012), Uncovering the role of genomic "dark matter" in human disease., J. Clin. Invest.
  107. Mizutani (2012), Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells., PLoS ONE
  108. Motterle (2012), Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells., Hum. Mol. Genet.
  109. Mußotter (2012), Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions., BMC Med. Genet.
  110. Nakano (2012), Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese., PLoS ONE
  111. Qureshi (2012), Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease., Nat. Rev. Neurosci.
  112. Talkowski (2012), Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities., Am. J. Hum. Genet.
  113. Tani (2012), Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals., Genome Res.
  114. Wiggs (2012), Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma., PLoS Genet.
  115. Zhang (2012), Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population., Stroke
  116. Zhuang (2012), Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease., PLoS ONE
  117. Aguilo (2011), Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression., Cancer Res.
  118. Burdon (2011), Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1., Nat. Genet.
  119. Kotake (2011), Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene., Oncogene
  120. Nakagawa (2011), eXIST with matrix-associated proteins., Trends Cell Biol.
  121. Pasmant (2011), ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS., FASEB J.
  122. Pasmant (2011), Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1., J. Natl. Cancer Inst.
  123. Zong (2011), RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs., RNA Biol
  124. Cunnington (2010), Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression., PLoS Genet.
  125. Hashikata (2010), Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients., Stroke
  126. Holdt (2010), ANRIL expression is associated with atherosclerosis risk at chromosome 9p21., Arterioscler. Thromb. Vasc. Biol.
  127. Popov (2010), Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health., Epigenetics
  128. Visel (2010), Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice., Nature
  129. Yap (2010), Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a., Mol. Cell
  130. Folkersen (2009), Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants., PLoS ONE
  131. Jarinova (2009), Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus., Arterioscler. Thromb. Vasc. Biol.
  132. Liu (2009), INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis., PLoS ONE
  133. Schaefer (2009), Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis., PLoS Genet.
  134. Shete (2009), Genome-wide association study identifies five susceptibility loci for glioma., Nat. Genet.
  135. Broadbent (2008), Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p., Hum. Mol. Genet.
  136. Yu (2008), Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA., Nature
  137. McPherson (2007), A common allele on chromosome 9 associated with coronary heart disease., Science
  138. Pasmant (2007), Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF., Cancer Res.


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
3.1 lnc-MTAP-1:31
4.0 CDKN2B-AS1:30
4.1 CDKN2B-AS1:30
5.0 CDKN2B-AS1:30
5.1 CDKN2B-AS1:30
5.2 CDKN2B-AS1:30