Transcript: ATXN8OS:6

Basic information

LNCipedia transcript ID: ATXN8OS:6 
HGNC Gene Symbol: ATXN8OS    
HGNC Full Gene Name: ATXN8 opposite strand lncRNA
Ensembl Gene ID: ENSG00000230223
Ensembl Transcript ID: ENST00000424524
Location (hg38): chr13:70107912-70131546
Strand: +
Class: antisense
Sequence Ontology term: antisense_lncRNA
Transcript size: 1236 bp
Exons: 4
Sources: Gencode v13; Ensembl release 68 - Jul 2012; NONCODE v4; Ensembl release 75 - Feb 2014; Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018
Alternative transcript names: ENST00000424524.1; ATXN8OS-001; OTTHUMT00000045232.1; NONHSAT034253
Alternative gene names: ENSG00000230223.1; ATXN8OS; OTTHUMG00000017057.1; ENSG00000230223.2; ENSG00000230223.6; NCRNA00003


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -91.6813 non-coding 
CPAT coding probability 4.19% non-coding 
Bazzini small ORFs 0 non-coding 

In stringent set: yes

Locus conservation

Locus conservation?
ATXN8OS:6 yes no no no

Available literature

  1. Imam (2015), The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins., Sci Rep
  2. Quek (2015), lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs., Nucleic Acids Res.
  3. Qureshi (2012), Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease., Nat. Rev. Neurosci.
  4. Daughters (2009), RNA gain-of-function in spinocerebellar ataxia type 8., PLoS Genet.
  5. Chen (2008), SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology., Brain Res.
  6. Moseley (2006), Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8., Nat. Genet.
  7. Mutsuddi (2004), The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila., Curr. Biol.
  8. Benzow (2002), The KLHL1-antisense transcript ( KLHL1AS) is evolutionarily conserved., Mamm. Genome
  9. Nemes (2000), The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)., Hum. Mol. Genet.
  10. Koob (1999), An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8), Nat. Genet.


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
3.1 lnc-BORA-3:2
4.0 ATXN8OS:6
4.1 ATXN8OS:6
5.0 ATXN8OS:6
5.1 ATXN8OS:6
5.2 ATXN8OS:6