Transcript: GAS5:24

Basic information

LNCipedia transcript ID: GAS5:24 
HGNC Gene Symbol: GAS5    
HGNC Full Gene Name: growth arrest specific 5
Ensembl Gene ID: ENSG00000234741
Ensembl Transcript ID: ENST00000451607
Location (hg38): chr1:173864034-173867729
Strand: -
Class: bidirectional
Sequence Ontology term:
Transcript size: 1007 bp
Exons: 12
Sources: Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018
Alternative transcript names: ENST00000451607.5
Alternative gene names: ENSG00000234741.7; GAS5; SNHG2; NCRNA00030


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites non-coding 
PhyloCSF score -22.8552 non-coding 
CPAT coding probability 1.25% non-coding 
Bazzini small ORFs 1 coding 
covF1Prop0.607843137
orfFrame11.12086476
seqAAMNGMVLGADAVWLWIAPYGQLCPQGRMRIATEVLKSKPNSSHWHTGIRQKAGS

In stringent set: no

Locus conservation

Locus conservation?
GAS5:24 no no no no

Available literature

  1. Chang (2016), Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin., Mol Med Rep
  2. Fayda (2016), Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?, Tumour Biol.
  3. Han (2016), Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects., Tumour Biol.
  4. Hu (2016), Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21., Tumour Biol.
  5. Ma (2016), The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers., Tumour Biol.
  6. Thorenoor (2016), Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer., Oncotarget
  7. Bo (2015), Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma., Oncotarget
  8. Cabili (2015), Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution., Genome Biol.
  9. Cai (2015), Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway., Onco Targets Ther
  10. Carter (2015), Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus., BBA Clin
  11. Chen (2015), Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity., Sci Rep
  12. Chen (2015), Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA., Sci Rep
  13. Dong (2015), The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression., J Hematol Oncol
  14. Gao (2015), Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway., Oncol. Rep.
  15. Ge (2015), MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma., PLoS Genet.
  16. Glover (2015), Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence., Endocr. Relat. Cancer
  17. Guo (2015), LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells., J. Biomed. Sci.
  18. Guo (2015), Competing endogenous RNA networks and gastric cancer., World J. Gastroenterol.
  19. He (2015), An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes., Nucleic Acids Res.
  20. Imam (2015), The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins., Sci Rep
  21. Işın (2015), Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease., Front Genet
  22. Keenan (2015), Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells., Can. J. Physiol. Pharmacol.
  23. Li (2015), Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins., PLoS ONE
  24. Li (2015), Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma., Int J Clin Exp Pathol
  25. Liu (2015), Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer., Mol Biosyst
  26. Liu (2015), Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells., J. Neurooncol.
  27. Liu (2015), lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer., Sci Rep
  28. Liu (2015), Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1., Int J Clin Exp Pathol
  29. Liu (2015), Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer., Int J Clin Exp Pathol
  30. Lucafo (2015), Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response., Curr. Mol. Med.
  31. Malouf (2015), Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing., Mol Oncol
  32. Na (2015), Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway., Int J Clin Exp Med
  33. Pastori (2015), The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation., Proc. Natl. Acad. Sci. U.S.A.
  34. Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
  35. Peng (2015), The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto's Thyroiditis., Sci Rep
  36. Peschansky (2015), Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells., Front Genet
  37. Pickard (2015), Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA., Genes (Basel)
  38. Ragusa (2015), Non-coding landscapes of colorectal cancer., World J. Gastroenterol.
  39. Shi (2015), A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer., Mol. Carcinog.
  40. Shi (2015), Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis., Int J Clin Exp Pathol
  41. Sun (2015), Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma., Int J Clin Exp Pathol
  42. Tani (2015), Development of cytotoxicity-sensitive human cells using overexpression of long non-coding RNAs., J. Biosci. Bioeng.
  43. Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
  44. Tao (2015), Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma., Carcinogenesis
  45. Wang (2015), Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer., Sci Rep
  46. Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
  47. Wei (2015), Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor., Oncotarget
  48. Wong (2015), Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma., Mol. Cancer
  49. Xie (2015), Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression., Oncotarget
  50. Xue (2015), Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma., Int J Clin Exp Pathol
  51. Yacqub-Usman (2015), Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells., Prostate
  52. Yan (2015), Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma., Int J Clin Exp Pathol
  53. Yang (2015), High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion., Eur Rev Med Pharmacol Sci
  54. Ye (2015), Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance., Int J Clin Exp Med
  55. Yu (2015), Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma., World J. Gastroenterol.
  56. Yu (2015), Long Non-coding RNA Growth Arrest-specific Transcript 5 (GAS5) Inhibits Liver Fibrogenesis through a Mechanism of Competing Endogenous RNA., J. Biol. Chem.
  57. Yu (2015), Long non-coding RNA growth arrest-specific transcript 5 in tumor biology., Oncol Lett
  58. Zhang (2015), Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma., PLoS ONE
  59. Zhao (2015), Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer., Int J Clin Exp Pathol
  60. Zhao (2015), Gas5 Exerts Tumor-suppressive Functions in Human Glioma Cells by Targeting miR-222., Mol. Ther.
  61. Zhou (2015), Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma., J Genet Genomics
  62. Cao (2014), Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer., Int J Clin Exp Pathol
  63. Chiyomaru (2014), Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells., J. Biol. Chem.
  64. DeOcesano-Pereira (2014), Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis., Nucleic Acids Res.
  65. Gezer (2014), Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes., Cell Biol. Int.
  66. Hu (2014), The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation., PLoS ONE
  67. Hudson (2014), The structure, function and evolution of proteins that bind DNA and RNA., Nat. Rev. Mol. Cell Biol.
  68. Hudson (2014), Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate., Nat Commun
  69. Isin (2014), Investigation of circulating lncRNAs in B-cell neoplasms., Clin. Chim. Acta
  70. Krell (2014), Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer., PLoS ONE
  71. Li (2014), A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β., Cancer Cell
  72. Li (2014), A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses., PLoS ONE
  73. Li (2014), Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma., Int J Clin Exp Pathol
  74. Li (2014), Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets., Front Bioeng Biotechnol
  75. Ma (2014), Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer., Mol. Cancer
  76. Malek (2014), Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer., Oncotarget
  77. Mourtada-Maarabouni (2014), Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells., Clin Lymphoma Myeloma Leuk
  78. Pickard (2014), Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy., Breast Cancer Res. Treat.
  79. Renganathan (2014), GAS5 long non-coding RNA in malignant pleural mesothelioma., Mol. Cancer
  80. Song (2014), A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis., J. Orthop. Res.
  81. Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
  82. Sun (2014), Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer., BMC Cancer
  83. Tu (2014), Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma., Int J Clin Exp Pathol
  84. Wang (2014), Exploring the stability of long intergenic non-coding RNA in K562 cells by comparative studies of RNA-Seq datasets., Biol. Direct
  85. Xing (2014), Identification of long noncoding RNA associated with osteoarthritis in humans., Orthop Surg
  86. Yin (2014), Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer., Med. Oncol.
  87. You (2014), MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1., Indian J Cancer
  88. Zhou (2014), An emerging understanding of long noncoding RNAs in kidney cancer., J. Cancer Res. Clin. Oncol.
  89. Beato (2013), A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes., Transcription
  90. Cao (2013), Analysis of long non-coding RNA expression profiles in gastric cancer., World J. Gastroenterol.
  91. Du (2013), Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer., Nat. Struct. Mol. Biol.
  92. Kapusta (2013), Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs., PLoS Genet.
  93. Liu (2013), LncRNA loc285194 is a p53-regulated tumor suppressor., Nucleic Acids Res.
  94. Liu (2013), Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6., PLoS ONE
  95. Lu (2013), Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6., Cell Tissue Res.
  96. Mourtada-Maarabouni (2013), Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5., Biomed Res Int
  97. Pickard (2013), Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines., Biochim. Biophys. Acta
  98. Qi (2013), Low expression of LOC285194 is associated with poor prognosis in colorectal cancer., J Transl Med
  99. Qiao (2013), Long non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma., Asian Pac. J. Cancer Prev.
  100. Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
  101. Zhang (2013), A long non-coding RNA signature in glioblastoma multiforme predicts survival., Neurobiol. Dis.
  102. Zhang (2013), Negative regulation of lncRNA GAS5 by miR-21., Cell Death Differ.
  103. Özgür (2013), Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells., Clin. Exp. Med.
  104. Mizutani (2012), Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells., PLoS ONE
  105. Wang (2011), Molecular mechanisms of long noncoding RNAs., Mol. Cell
  106. Smith (1998), Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes., Mol. Cell. Biol.


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
4.0 GAS5:24
4.1 GAS5:24
5.0 GAS5:24
5.1 GAS5:24
5.2 GAS5:24