Transcript: GAS5:24
Basic information
LNCipedia transcript ID: GAS5:24
HGNC Gene Symbol: GAS5
HGNC Full Gene Name:
growth arrest specific 5
Ensembl Gene ID:
ENSG00000234741
Ensembl Transcript ID:
ENST00000451607
Location (hg38): chr1:173864034-173867729
Strand: -
Class: bidirectional
Sequence Ontology term:
Transcript size: 1007 bp
Exons: 12
Sources: Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018
Alternative transcript names: ENST00000451607.5
Alternative gene names: ENSG00000234741.7; GAS5; SNHG2; NCRNA00030
RNA sequence:
Structure:
Protein coding potential
In stringent set: no
Locus conservation
Locus conservation? | ||||
---|---|---|---|---|
GAS5:24 | no | no | no | no |
Available literature
- Chang (2016), Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin., Mol Med Rep
- Fayda (2016), Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?, Tumour Biol.
- Han (2016), Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects., Tumour Biol.
- Hu (2016), Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21., Tumour Biol.
- Ma (2016), The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers., Tumour Biol.
- Thorenoor (2016), Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer., Oncotarget
- Bo (2015), Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma., Oncotarget
- Cabili (2015), Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution., Genome Biol.
- Cai (2015), Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway., Onco Targets Ther
- Carter (2015), Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus., BBA Clin
- Chen (2015), Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity., Sci Rep
- Chen (2015), Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA., Sci Rep
- Dong (2015), The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression., J Hematol Oncol
- Gao (2015), Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway., Oncol. Rep.
- Ge (2015), MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma., PLoS Genet.
- Glover (2015), Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence., Endocr. Relat. Cancer
- Guo (2015), LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells., J. Biomed. Sci.
- Guo (2015), Competing endogenous RNA networks and gastric cancer., World J. Gastroenterol.
- He (2015), An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes., Nucleic Acids Res.
- Imam (2015), The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins., Sci Rep
- Işın (2015), Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease., Front Genet
- Keenan (2015), Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells., Can. J. Physiol. Pharmacol.
- Li (2015), Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins., PLoS ONE
- Li (2015), Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma., Int J Clin Exp Pathol
- Liu (2015), Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer., Mol Biosyst
- Liu (2015), Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells., J. Neurooncol.
- Liu (2015), lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer., Sci Rep
- Liu (2015), Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1., Int J Clin Exp Pathol
- Liu (2015), Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer., Int J Clin Exp Pathol
- Lucafo (2015), Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response., Curr. Mol. Med.
- Malouf (2015), Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing., Mol Oncol
- Na (2015), Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway., Int J Clin Exp Med
- Pastori (2015), The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation., Proc. Natl. Acad. Sci. U.S.A.
- Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
- Peng (2015), The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto's Thyroiditis., Sci Rep
- Peschansky (2015), Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells., Front Genet
- Pickard (2015), Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA., Genes (Basel)
- Ragusa (2015), Non-coding landscapes of colorectal cancer., World J. Gastroenterol.
- Shi (2015), A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer., Mol. Carcinog.
- Shi (2015), Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis., Int J Clin Exp Pathol
- Sun (2015), Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma., Int J Clin Exp Pathol
- Tani (2015), Development of cytotoxicity-sensitive human cells using overexpression of long non-coding RNAs., J. Biosci. Bioeng.
- Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
- Tao (2015), Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma., Carcinogenesis
- Wang (2015), Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer., Sci Rep
- Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
- Wei (2015), Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor., Oncotarget
- Wong (2015), Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma., Mol. Cancer
- Xie (2015), Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression., Oncotarget
- Xue (2015), Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma., Int J Clin Exp Pathol
- Yacqub-Usman (2015), Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells., Prostate
- Yan (2015), Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma., Int J Clin Exp Pathol
- Yang (2015), High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion., Eur Rev Med Pharmacol Sci
- Ye (2015), Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance., Int J Clin Exp Med
- Yu (2015), Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma., World J. Gastroenterol.
- Yu (2015), Long Non-coding RNA Growth Arrest-specific Transcript 5 (GAS5) Inhibits Liver Fibrogenesis through a Mechanism of Competing Endogenous RNA., J. Biol. Chem.
- Yu (2015), Long non-coding RNA growth arrest-specific transcript 5 in tumor biology., Oncol Lett
- Zhang (2015), Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma., PLoS ONE
- Zhao (2015), Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer., Int J Clin Exp Pathol
- Zhao (2015), Gas5 Exerts Tumor-suppressive Functions in Human Glioma Cells by Targeting miR-222., Mol. Ther.
- Zhou (2015), Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma., J Genet Genomics
- Cao (2014), Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer., Int J Clin Exp Pathol
- Chiyomaru (2014), Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells., J. Biol. Chem.
- DeOcesano-Pereira (2014), Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis., Nucleic Acids Res.
- Gezer (2014), Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes., Cell Biol. Int.
- Hu (2014), The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation., PLoS ONE
- Hudson (2014), The structure, function and evolution of proteins that bind DNA and RNA., Nat. Rev. Mol. Cell Biol.
- Hudson (2014), Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate., Nat Commun
- Isin (2014), Investigation of circulating lncRNAs in B-cell neoplasms., Clin. Chim. Acta
- Krell (2014), Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer., PLoS ONE
- Li (2014), A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β., Cancer Cell
- Li (2014), A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses., PLoS ONE
- Li (2014), Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma., Int J Clin Exp Pathol
- Li (2014), Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets., Front Bioeng Biotechnol
- Ma (2014), Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer., Mol. Cancer
- Malek (2014), Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer., Oncotarget
- Mourtada-Maarabouni (2014), Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells., Clin Lymphoma Myeloma Leuk
- Pickard (2014), Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy., Breast Cancer Res. Treat.
- Renganathan (2014), GAS5 long non-coding RNA in malignant pleural mesothelioma., Mol. Cancer
- Song (2014), A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis., J. Orthop. Res.
- Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
- Sun (2014), Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer., BMC Cancer
- Tu (2014), Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma., Int J Clin Exp Pathol
- Wang (2014), Exploring the stability of long intergenic non-coding RNA in K562 cells by comparative studies of RNA-Seq datasets., Biol. Direct
- Xing (2014), Identification of long noncoding RNA associated with osteoarthritis in humans., Orthop Surg
- Yin (2014), Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer., Med. Oncol.
- You (2014), MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1., Indian J Cancer
- Zhou (2014), An emerging understanding of long noncoding RNAs in kidney cancer., J. Cancer Res. Clin. Oncol.
- Beato (2013), A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes., Transcription
- Cao (2013), Analysis of long non-coding RNA expression profiles in gastric cancer., World J. Gastroenterol.
- Du (2013), Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer., Nat. Struct. Mol. Biol.
- Kapusta (2013), Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs., PLoS Genet.
- Liu (2013), LncRNA loc285194 is a p53-regulated tumor suppressor., Nucleic Acids Res.
- Liu (2013), Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6., PLoS ONE
- Lu (2013), Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6., Cell Tissue Res.
- Mourtada-Maarabouni (2013), Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5., Biomed Res Int
- Pickard (2013), Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines., Biochim. Biophys. Acta
- Qi (2013), Low expression of LOC285194 is associated with poor prognosis in colorectal cancer., J Transl Med
- Qiao (2013), Long non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma., Asian Pac. J. Cancer Prev.
- Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
- Zhang (2013), A long non-coding RNA signature in glioblastoma multiforme predicts survival., Neurobiol. Dis.
- Zhang (2013), Negative regulation of lncRNA GAS5 by miR-21., Cell Death Differ.
- Özgür (2013), Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells., Clin. Exp. Med.
- Mizutani (2012), Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells., PLoS ONE
- Wang (2011), Molecular mechanisms of long noncoding RNAs., Mol. Cell
- Smith (1998), Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes., Mol. Cell. Biol.
LNCipedia transcript ID history
LNCipedia version | LNCipedia transcript ID |
---|---|
4.0 | GAS5:24 |
4.1 | GAS5:24 |
5.0 | GAS5:24 |
5.1 | GAS5:24 |
5.2 | GAS5:24 |