Transcript: HOTAIR:5

Basic information

LNCipedia transcript ID: HOTAIR:5 
LNCipedia gene ID: HOTAIR
RefSeq ID: NR_047518
Location (hg38): chr12:53962308-53968914
Strand: -
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 2337 bp
Exons: 4
Sources: NONCODE v4; Refseq - Dec 2014; Refseq - NCBI Annotation Release 106
Alternative transcript names: NONHSAT028509; NR_047518; NR_047518.1
Alternative gene names: HOXC-AS4; HOXC11-AS1; NCRNA00072; HOTAIR


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -38.4709 non-coding 
CPAT coding probability 55.55% coding 
Bazzini small ORFs 0 non-coding 

In stringent set: no

Locus conservation

Locus conservation?
HOTAIR:5 no no no no

Available literature

  1. Botti (2017), LncRNA HOTAIR as Prognostic Circulating Marker and Potential Therapeutic Target in Patients with Tumor Diseases., Curr Drug Targets
  2. Bayram (2016), A functional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study., Tumour Biol.
  3. Bhan (2016), Estradiol-Induced Transcriptional Regulation of Long Non-Coding RNA, HOTAIR., Methods Mol. Biol.
  4. Chang (2016), Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin., Mol Med Rep
  5. Choudhry (2016), Hypoxic regulation of the noncoding genome and NEAT1., Brief Funct Genomics
  6. Fang (2016), Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells., Lab. Invest.
  7. Fayda (2016), Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?, Tumour Biol.
  8. Fu (2016), Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways., Oncotarget
  9. Gao (2016), ROR functions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic cancer., Oncotarget
  10. Jiang (2016), The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1., Tumour Biol.
  11. Lennox (2016), Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides., Nucleic Acids Res.
  12. Li (2016), Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer., Tumour Biol.
  13. Liu (2016), Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract., Toxicol. Lett.
  14. Liu (2016), The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster., Nucleic Acids Res.
  15. Mohankumar (2016), Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer., Brief Funct Genomics
  16. Pan (2016), A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility., Mol. Carcinog.
  17. Sun (2016), Involvement of lncRNA dysregulation in gastric cancer., Histol. Histopathol.
  18. Thorenoor (2016), Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer., Oncotarget
  19. Xie (2016), Long non-coding RNAs in colorectal cancer., Oncotarget
  20. Xue (2016), LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer., Oncogene
  21. Yang (2016), Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer., Oncol. Rep.
  22. Zhang (2016), Long non-coding RNA chromogenic in situ hybridisation signal pattern correlation with breast tumour pathology., J. Clin. Pathol.
  23. Abba (2015), A Molecular Portrait of High-Grade Ductal Carcinoma In Situ., Cancer Res.
  24. Bayram (2015), Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population., Tumour Biol.
  25. Bayram (2015), A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study., Fam. Cancer
  26. Bhan (2015), LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer., Biochim. Biophys. Acta
  27. Cabanski (2015), Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function., RNA Biol
  28. Carter (2015), Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus., BBA Clin
  29. Chen (2015), Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells., Cell. Physiol. Biochem.
  30. Chen (2015), SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma., Sci Rep
  31. Chen (2015), Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity., Sci Rep
  32. Chen (2015), Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA., Sci Rep
  33. Chen (2015), Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating β-catenin mediated by upregulated HOTAIR., Int J Clin Exp Pathol
  34. Cheng (2015), The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration., Oncotarget
  35. Chillón (2015), Native Purification and Analysis of Long RNAs., Meth. Enzymol.
  36. Conigliaro (2015), CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA., Mol. Cancer
  37. Dang (2015), Expression and clinical significance of long non-coding RNA HNF1A-AS1 in human gastric cancer., World J Surg Oncol
  38. Ding (2015), Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients., Oncol Lett
  39. Ding (2015), Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades., J. Exp. Clin. Cancer Res.
  40. Du (2015), The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population., Oncotarget
  41. Díaz-Beyá (2015), The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature., Oncotarget
  42. Fan (2015), Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis., Genome Biol.
  43. Fan (2015), Erratum to: Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis., Genome Biol.
  44. Fang (2015), Probing Xist RNA Structure in Cells Using Targeted Structure-Seq., PLoS Genet.
  45. Fiscon (2015), MONSTER v1.1: a tool to extract and search for RNA non-branching structures., BMC Genomics
  46. Fu (2015), Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling., J. Hepatol.
  47. Gaiti (2015), Dynamic and Widespread lncRNA Expression in a Sponge and the Origin of Animal Complexity., Mol. Biol. Evol.
  48. Gan (2015), Focusing on long noncoding RNA dysregulation in gastric cancer., Tumour Biol.
  49. Gandhy (2015), Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC., Oncotarget
  50. Ge (2015), MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma., PLoS Genet.
  51. Guerrieri (2015), Long non-coding RNAs era in liver cancer., World J Hepatol
  52. Guo (2015), Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China., Tumour Biol.
  53. Guo (2015), Competing endogenous RNA networks and gastric cancer., World J. Gastroenterol.
  54. Guo (2015), Comprehensive analysis of lncRNA-mRNA co-expression patterns identifies immune-associated lncRNA biomarkers in ovarian cancer malignant progression., Sci Rep
  55. Gökmen-Polar (2015), Prognostic impact of HOTAIR expression is restricted to ER-negative breast cancers., Sci Rep
  56. Hajjari (2015), HOTAIR: an oncogenic long non-coding RNA in different cancers., Cancer Biol Med
  57. Hao (2015), Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma., BMC Cancer
  58. Hao (2015), HOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis., Int J Clin Exp Pathol
  59. Heubach (2015), The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells., Mol. Cancer
  60. Hu (2015), A common set of distinct features that characterize noncoding RNAs across multiple species., Nucleic Acids Res.
  61. Hu (2015), Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma., J. Exp. Clin. Cancer Res.
  62. Hu (2015), Downregulation of NUF2 inhibits tumor growth and induces apoptosis by regulating lncRNA AF339813., Int J Clin Exp Pathol
  63. Hu (2015), NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2., Oncotarget
  64. Hua (2015), High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma., Int J Clin Exp Pathol
  65. Huang (2015), HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma., Oncotarget
  66. Imam (2015), The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins., Sci Rep
  67. Iyer (2015), The landscape of long noncoding RNAs in the human transcriptome., Nat. Genet.
  68. Jiang (2015), LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data., BMC Genomics
  69. Jiang (2015), Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations., Oncotarget
  70. Jiang (2015), Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1., Mol Med Rep
  71. Jiao (2015), Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line., Oncol Lett
  72. Jing (2015), HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer., Tumour Biol.
  73. Ke (2015), Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326., Oncotarget
  74. Kim (2015), Long non-coding RNA HOTAIR is associated with human cervical cancer progression., Int. J. Oncol.
  75. Kim (2015), Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs., PLoS ONE
  76. Kong (2015), Targeting HOTAIR Induces Mitochondria Related Apoptosis and Inhibits Tumor Growth in Head and Neck Squamous Cell Carcinoma in vitro and in vivo., Curr. Mol. Med.
  77. Koufariotis (2015), A catalogue of novel bovine long noncoding RNA across 18 tissues., PLoS ONE
  78. Li (2015), Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior., Pituitary
  79. Li (2015), A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer., Tumour Biol.
  80. Li (2015), MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks., Drug Metab. Rev.
  81. Li (2015), Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population., Oncotarget
  82. Li (2015), Expression of long non-coding RNA DLX6-AS1 in lung adenocarcinoma., Cancer Cell Int.
  83. Li (2015), Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer., Diagn Pathol
  84. Li (2015), Prognostic role of HOTAIR in four estrogen-dependent malignant tumors: a meta-analysis., Onco Targets Ther
  85. Li (2015), LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2., Oncotarget
  86. Li (2015), LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns., Oncotarget
  87. Li (2015), Erratum to: Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer., Tumour Biol.
  88. Liu (2015), Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract., Toxicol. Appl. Pharmacol.
  89. Liu (2015), Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1., Int J Clin Exp Pathol
  90. Liu (2015), Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer., Int J Clin Exp Pathol
  91. Ma (2015), Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes., Nat. Methods
  92. Malouf (2015), Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing., Mol Oncol
  93. Martínez-Fernández (2015), Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer., Clin Epigenetics
  94. Martínez-Fernández (2015), EZH2 in Bladder Cancer, a Promising Therapeutic Target., Int J Mol Sci
  95. Na (2015), Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway., Int J Clin Exp Med
  96. Nie (2015), Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression., Mol. Cancer Ther.
  97. Nwigwe (2015), Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions., PLoS ONE
  98. Oliver (2015), Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype., Cereb. Cortex
  99. Pastori (2015), The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation., Proc. Natl. Acad. Sci. U.S.A.
  100. Pedram Fatemi (2015), Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen., J Biomol Screen
  101. Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
  102. Peng (2015), Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression., J. Exp. Clin. Cancer Res.
  103. Peschansky (2015), Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells., Front Genet
  104. Qiu (2015), The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis., Exp. Cell Res.
  105. Qiu (2015), A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27., Cell Death Dis
  106. Quek (2015), lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs., Nucleic Acids Res.
  107. Ragusa (2015), Non-coding landscapes of colorectal cancer., World J. Gastroenterol.
  108. Richards (2015), A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer., Oncotarget
  109. Rupaimoole (2015), Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis., Cell Rep
  110. Scarola (2015), Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA., Nat Commun
  111. Sharma (2015), Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis., Sci Rep
  112. Shen (2015), Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival., Cancers (Basel)
  113. Shi (2015), Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis., Int J Clin Exp Pathol
  114. Shi (2015), Microvascular invasion in hepatocellular carcinoma overexpression promotes cell proliferation and inhibits cell apoptosis of hepatocellular carcinoma via inhibiting miR-199a expression., Onco Targets Ther
  115. Silva (2015), The Clinical Relevance of Long Non-Coding RNAs in Cancer., Cancers (Basel)
  116. Smolle (2015), Long Non-Coding RNAs in Endometrial Carcinoma., Int J Mol Sci
  117. Somarowthu (2015), HOTAIR forms an intricate and modular secondary structure., Mol. Cell
  118. Song (2015), PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis., Clin. Exp. Med.
  119. Song (2015), Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells., Biochem. Biophys. Res. Commun.
  120. Sugihara (2015), Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma., Int J Mol Sci
  121. Sun (2015), Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma., Int J Clin Exp Pathol
  122. Sun (2015), Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer., Cell Death Dis
  123. Sun (2015), A potential prognostic long non-coding RNA signature to predict metastasis-free survival of breast cancer patients., Sci Rep
  124. Tan (2015), Reprogramming during epithelial to mesenchymal transition under the control of TGFβ., Cell Adh Migr
  125. Tan (2015), HOTAIR inhibited intracellular Ca2+ via regulation of Cav1.2 channel in human cardiomyocytes., Cell. Mol. Biol. (Noisy-le-grand)
  126. Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
  127. Teschendorff (2015), HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer., Genome Med
  128. Tong (2015), Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma., Mol. Cancer
  129. Wang (2015), Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma., Mol. Cells
  130. Wang (2015), Prognostic value of long noncoding RNA HOTAIR in digestive system malignancies., J. Gastroenterol. Hepatol.
  131. Wang (2015), Downregulated lincRNA HOTAIR expression in ovarian cancer stem cells decreases its tumorgeniesis and metastasis by inhibiting epithelial-mesenchymal transition., Cancer Cell Int.
  132. Wang (2015), Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR., Oncotarget
  133. Wang (2015), Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection., Proc. Natl. Acad. Sci. U.S.A.
  134. Wang (2015), Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer., Sci Rep
  135. Wang (2015), LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia., Sci Rep
  136. Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
  137. Wang (2015), LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer., Oncotarget
  138. Wang (2015), The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH., Sci Rep
  139. Wang (2015), Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma., PLoS ONE
  140. Wei (2015), Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor., Oncotarget
  141. Werner (2015), Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes., Cell Rep
  142. Wongtrakoongate (2015), Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes., PLoS Genet.
  143. Wu (2015), The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma., Oncotarget
  144. Wu (2015), Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma., Int. J. Oncol.
  145. Wu (2015), Expression of long noncoding RNA-HOX transcript antisense intergenic RNA in oral squamous cell carcinoma and effect on cell growth., Tumour Biol.
  146. Wu (2015), Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia., Oncol Lett
  147. Xie (2015), Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression., Oncotarget
  148. Xing (2015), Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia., FEBS Lett.
  149. Xue (2015), Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer., Mutagenesis
  150. Xue (2015), Genome-wide analysis of long noncoding RNA signature in human colorectal cancer., Gene
  151. Xue (2015), Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma., Int J Clin Exp Pathol
  152. Yamamoto (2015), Breast Cancer: Radiogenomic Biomarker Reveals Associations among Dynamic Contrast-enhanced MR Imaging, Long Noncoding RNA, and Metastasis., Radiology
  153. Yan (2015), Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma., Int J Clin Exp Pathol
  154. Yan (2015), Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population., Cancer Epidemiol
  155. Yang (2015), Overexpression of Long Non-Coding RNA ZXF2 Promotes Lung Adenocarcinoma Progression Through c-Myc Pathway., Cell. Physiol. Biochem.
  156. Yang (2015), Expression profile of long non-coding RNAs is altered in endometrial cancer., Int J Clin Exp Med
  157. Yang (2015), High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion., Eur Rev Med Pharmacol Sci
  158. Ye (2015), Evaluation of four genetic variants in han chinese subjects with high myopia., J Ophthalmol
  159. Ye (2015), Enhancing HOTAIR/MiR-10b Drives Normal Liver Stem Cells Toward a Tendency to Malignant Transformation Through Inducing Epithelial- to-Mesenchymal Transition., Rejuvenation Res
  160. Ye (2015), Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance., Int J Clin Exp Med
  161. Yin (2015), SnoVectors for nuclear expression of RNA., Nucleic Acids Res.
  162. Yin (2015), Expression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers--Hepatocellular Carcinoma and Cervical Cancer., PLoS ONE
  163. Yu (2015), Long non-coding RNAs and hepatocellular carcinoma., Mol Clin Oncol
  164. Yu (2015), Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma., World J. Gastroenterol.
  165. Yu (2015), Long non-coding RNA HOTAIR: A novel oncogene (Review)., Mol Med Rep
  166. Yu (2015), Long non-coding RNA growth arrest-specific transcript 5 in tumor biology., Oncol Lett
  167. Zhai (2015), Long noncoding RNA MALAT1 as a putative biomarker of lymph node metastasis: a meta-analysis., Int J Clin Exp Med
  168. Zhang (2015), Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner., Oncotarget
  169. Zhang (2015), HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1., Mol. Cancer Ther.
  170. Zhang (2015), PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis., Cancer Res.
  171. Zhang (2015), Circulating DNA of HOTAIR in serum is a novel biomarker for breast cancer., Breast Cancer Res. Treat.
  172. Zhang (2015), LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis., Int J Clin Exp Med
  173. Zhang (2015), LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer., Cell Rep
  174. Zhang (2015), Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value., Biomed Res Int
  175. Zhang (2015), Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer., Int J Clin Exp Pathol
  176. Zhang (2015), Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells., Int J Clin Exp Med
  177. Zhao (2015), Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer., Cell Cycle
  178. Zhao (2015), HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy., Am J Transl Res
  179. Zheng (2015), Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells., Mol. Cell Proteomics
  180. Zhou (2015), Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1α activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer., Tumour Biol.
  181. Zhou (2015), Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer., Sci Rep
  182. Zhou (2015), Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma., Sci Rep
  183. Zhu (2015), [Effects of long non-coding RNA-HOTAIR on the cell cycle and invasiveness of prostate cancer]., Zhonghua Nan Ke Xue
  184. Zhu (2015), Ectopic expressed long non-coding RNA H19 contributes to malignant cell behavior of ovarian cancer., Int J Clin Exp Pathol
  185. Zhuang (2015), Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells., Mol. Carcinog.
  186. Zou (2015), [Long noncoding RNA HOTAIR modulates the function of trophoblast cells in pre-eclampsia]., Sichuan Da Xue Xue Bao Yi Xue Ban
  187. Alaimo (2014), ncPred: ncRNA-Disease Association Prediction through Tripartite Network-Based Inference., Front Bioeng Biotechnol
  188. Almlöf (2014), Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes., PLoS ONE
  189. Barnhill (2014), High expression of CAI2, a 9p21-embedded long noncoding RNA, contributes to advanced-stage neuroblastoma., Cancer Res.
  190. Basu (2014), Using amino-labeled nucleotide probes for simultaneous single molecule RNA-DNA FISH., PLoS ONE
  191. Bhan (2014), Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo., J. Steroid Biochem. Mol. Biol.
  192. Brunner (2014), A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions., Genome Biol.
  193. Cai (2014), Long noncoding RNA HOTAIR can serve as a common molecular marker for lymph node metastasis: a meta-analysis., Tumour Biol.
  194. Cai (2014), HOTAIR: a cancer-related long non-coding RNA., Neoplasma
  195. Cao (2014), [Genome wide screening and characterization of long non-coding RNAs in esophageal cancer]., Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  196. Carrion (2014), The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes., PLoS ONE
  197. Chakravadhanula (2014), Expression of the HOX genes and HOTAIR in atypical teratoid rhabdoid tumors and other pediatric brain tumors., Cancer Genet
  198. Chen (2014), Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma., Med. Oncol.
  199. Chi (2014), Role of BC040587 as a predictor of poor outcome in breast cancer., Cancer Cell Int.
  200. Chiyomaru (2014), Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells., J. Biol. Chem.
  201. Cifuentes-Rojas (2014), Regulatory interactions between RNA and polycomb repressive complex 2., Mol. Cell
  202. Cogill (2014), Co-expression Network Analysis of Human lncRNAs and Cancer Genes., Cancer Inform
  203. Collier (2014), Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet., J. Immunol.
  204. Davidovich (2014), A dimeric state for PRC2., Nucleic Acids Res.
  205. Deng (2014), Up-regulation of 91H promotes tumor metastasis and predicts poor prognosis for patients with colorectal cancer., PLoS ONE
  206. Deng (2014), Prognostic value of long non-coding RNA HOTAIR in various cancers., PLoS ONE
  207. Ding (2014), Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells., Int J Mol Sci
  208. Ding (2014), Long intergenic non-coding RNAs (LincRNAs) identified by RNA-seq in breast cancer., PLoS ONE
  209. Ding (2014), Expression of long non-coding RNA LOC285194 and its prognostic significance in human pancreatic ductal adenocarcinoma., Int J Clin Exp Pathol
  210. Divoux (2014), Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation., Obesity (Silver Spring)
  211. Dryden (2014), Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C., Genome Res.
  212. Emadi-Andani (2014), Association of HOTAIR expression in gastric carcinoma with invasion and distant metastasis., Adv Biomed Res
  213. Feng (2014), Methods for the study of long noncoding RNA in cancer cell signaling., Methods Mol. Biol.
  214. Garzon (2014), Expression and prognostic impact of lncRNAs in acute myeloid leukemia., Proc. Natl. Acad. Sci. U.S.A.
  215. Gezer (2014), Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes., Cell Biol. Int.
  216. Guallar (2014), RNA-binding proteins in pluripotency, differentiation, and reprogramming., Front Biol (Beijing)
  217. Guo (2014), BRAF-activated long non-coding RNA contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition., Oncol Lett
  218. Halley (2014), Regulation of the apolipoprotein gene cluster by a long noncoding RNA., Cell Rep
  219. Han (2014), A long noncoding RNA protects the heart from pathological hypertrophy., Nature
  220. Han (2014), LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition., BMC Cancer
  221. He (2014), The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis., Int. J. Mol. Med.
  222. Hou (2014), Long noncoding RNAs expression patterns associated with chemo response to cisplatin based chemotherapy in lung squamous cell carcinoma patients., PLoS ONE
  223. Hu (2014), A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer., Cancer Cell
  224. Huang (2014), Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer., Arch. Gynecol. Obstet.
  225. Huang (2014), Lentivirus-mediated RNA interference targeting the long noncoding RNA HOTAIR inhibits proliferation and invasion of endometrial carcinoma cells in vitro and in vivo., Int. J. Gynecol. Cancer
  226. Hudson (2014), Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate., Nat Commun
  227. Isin (2014), Investigation of circulating lncRNAs in B-cell neoplasms., Clin. Chim. Acta
  228. Jiang (2014), LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation., Exp. Dermatol.
  229. Jiang (2014), The role of MALAT1 correlates with HPV in cervical cancer., Oncol Lett
  230. Kim (2014), Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5., Proc. Natl. Acad. Sci. U.S.A.
  231. Kretz (2014), RNA binding of PRC2: promiscuous or well ordered?, Mol. Cell
  232. Lau (2014), Viral-human chimeric transcript predisposes risk to liver cancer development and progression., Cancer Cell
  233. Lee (2014), Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma., Biochem. Biophys. Res. Commun.
  234. Li (2014), starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data., Nucleic Acids Res.
  235. Li (2014), A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β., Cancer Cell
  236. Li (2014), A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses., PLoS ONE
  237. Li (2014), Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma., Mol Med Rep
  238. Li (2014), Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation., PLoS ONE
  239. Li (2014), Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis., Breast Cancer Res.
  240. Li (2014), Long noncoding RNA GHET1 promotes the development of bladder cancer., Int J Clin Exp Pathol
  241. Li (2014), [Long noncoding RNAs in gene expression control]., Zhong Nan Da Xue Xue Bao Yi Xue Ban
  242. Li (2014), Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation., RNA Biol
  243. Li (2014), Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma., Int J Clin Exp Pathol
  244. Lin (2014), Long noncoding RNA expression in dermal papilla cells contributes to hairy gene regulation., Biochem. Biophys. Res. Commun.
  245. Liu (2014), Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer., Mol. Cancer
  246. Liu (2014), LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray., World J. Gastroenterol.
  247. Liu (2014), Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression., J. Natl. Cancer Inst.
  248. Loewen (2014), Functions of lncRNA HOTAIR in lung cancer., J Hematol Oncol
  249. Ma (2014), Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer., Mol. Cancer
  250. Malek (2014), Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer., Oncotarget
  251. Mathiyalagan (2014), Interplay of chromatin modifications and non-coding RNAs in the heart., Epigenetics
  252. Mazar (2014), The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells., Oncotarget
  253. Mehra (2014), A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer., Neoplasia
  254. Negishi (2014), A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins., PLoS ONE
  255. Okugawa (2014), Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis., Carcinogenesis
  256. Ono (2014), Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer., Cancer Med
  257. Pei (2014), Influence of curcumin on HOTAIR-mediated migration of human renal cell carcinoma cells., Asian Pac. J. Cancer Prev.
  258. Pestell (2014), Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo., Asian J. Androl.
  259. Peter (2014), Identification of differentially expressed long noncoding RNAs in bladder cancer., Clin. Cancer Res.
  260. Pircher (2014), Ribosome-associated ncRNAs: an emerging class of translation regulators., RNA Biol
  261. Porro (2014), TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres., Cell Rep
  262. Puvvula (2014), Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit., Nat Commun
  263. Qin (2014), Expression pattern of long non-coding RNAs in renal cell carcinoma revealed by microarray., PLoS ONE
  264. Qiu (2014), Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer., Gynecol. Oncol.
  265. Quinn (2014), Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification., Nat. Biotechnol.
  266. Quinodoz (2014), Long noncoding RNAs: an emerging link between gene regulation and nuclear organization., Trends Cell Biol.
  267. Roberts (2014), The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease., Philos. Trans. R. Soc. Lond., B, Biol. Sci.
  268. Seki (2014), A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells., PLoS ONE
  269. Song (2014), A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis., J. Orthop. Res.
  270. Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
  271. Sun (2014), A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies., Nucleic Acids Res.
  272. Svoboda (2014), HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients., Carcinogenesis
  273. Takahashi (2014), Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer., FEBS Open Bio
  274. Takahashi (2014), Widespread genome transcription: new possibilities for RNA therapies., Biochem. Biophys. Res. Commun.
  275. Tong (2014), Association of decreased expression of long non-coding RNA LOC285194 with chemoradiotherapy resistance and poor prognosis in esophageal squamous cell carcinoma., J Transl Med
  276. Tu (2014), Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma., Int J Clin Exp Pathol
  277. Wan (2014), Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study., Arthritis Res. Ther.
  278. Wang (2014), Exploring the stability of long intergenic non-coding RNA in K562 cells by comparative studies of RNA-Seq datasets., Biol. Direct
  279. Wang (2014), Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma., Med. Oncol.
  280. White (2014), Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer., Genome Biol.
  281. Wright (2014), A short guide to long non-coding RNA gene nomenclature., Hum. Genomics
  282. Wu (2014), Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer., Oncol. Rep.
  283. Wu (2014), Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells., Tumour Biol.
  284. Wu (2014), Long noncoding RNA HOTAIR involvement in cancer., Tumour Biol.
  285. Xie (2014), NONCODEv4: exploring the world of long non-coding RNA genes., Nucleic Acids Res.
  286. Xing (2014), Identification of long noncoding RNA associated with osteoarthritis in humans., Orthop Surg
  287. Xu (2014), Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma., Int. J. Biol. Sci.
  288. Xu (2014), Long noncoding RNA expression profiles of lung adenocarcinoma ascertained by microarray analysis., PLoS ONE
  289. Xu (2014), Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression., J Hematol Oncol
  290. Xu (2014), Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer., Medicine (Baltimore)
  291. Yan (2014), Upregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer., Tumour Biol.
  292. Yang (2014), Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency., Elife
  293. Yang (2014), Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1., Biochim. Biophys. Acta
  294. Yao (2014), Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers., Int J Mol Sci
  295. Yarmishyn (2014), HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome., BMC Genomics
  296. You (2014), Long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) as a foe and novel potential therapeutic target for endometrial carcinoma., Int. J. Gynecol. Cancer
  297. Zhang (2014), Long non-coding RNA HOTAIR in carcinogenesis and metastasis., Acta Biochim. Biophys. Sin. (Shanghai)
  298. Zhang (2014), The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer., Carcinogenesis
  299. Zhang (2014), MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway., Stem Cells
  300. Zhang (2014), Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: a meta-analysis., PLoS ONE
  301. Zhang (2014), Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers., BMC Genomics
  302. Zhao (2014), Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer., Eur Rev Med Pharmacol Sci
  303. Zhao (2014), A novel wnt regulatory axis in endometrioid endometrial cancer., Cancer Res.
  304. Zhao (2014), Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications., Sci Rep
  305. Zhou (2014), The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance., Acta Biochim. Biophys. Sin. (Shanghai)
  306. Alaei-Mahabadi (2013), Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs., Silence
  307. Amort (2013), Long non-coding RNAs as targets for cytosine methylation., RNA Biol
  308. Arita (2013), Circulating long non-coding RNAs in plasma of patients with gastric cancer., Anticancer Res.
  309. Batagov (2013), Role of genomic architecture in the expression dynamics of long noncoding RNAs during differentiation of human neuroblastoma cells., BMC Syst Biol
  310. Beato (2013), A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes., Transcription
  311. Bhan (2013), Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol., J. Mol. Biol.
  312. Bhartiya (2013), lncRNome: a comprehensive knowledgebase of human long noncoding RNAs., Database (Oxford)
  313. Bhattacharjee (2013), Combinatorial control of gene expression., Biomed Res Int
  314. Bird (2013), Genome biology: not drowning but waving., Cell
  315. Cao (2013), Integrated analysis of long noncoding RNA and coding RNA expression in esophageal squamous cell carcinoma., Int J Genomics
  316. Chen (2013), LncRNADisease: a database for long-non-coding RNA-associated diseases., Nucleic Acids Res.
  317. Chen (2013), Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis., Mol. Carcinog.
  318. Chiyomaru (2013), Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR., PLoS ONE
  319. Cui (2013), [Expression of long non-coding RNA HOTAIR mRNA in ovarian cancer]., Sichuan Da Xue Xue Bao Yi Xue Ban
  320. Dasen (2013), Long noncoding RNAs in development: solidifying the Lncs to Hox gene regulation., Cell Rep
  321. Davidovich (2013), Promiscuous RNA binding by Polycomb repressive complex 2., Nat. Struct. Mol. Biol.
  322. Dodd (2013), Digital quantitation of potential therapeutic target RNAs., Nucleic Acid Ther
  323. Du (2013), Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer., Nat. Struct. Mol. Biol.
  324. Endo (2013), Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer., PLoS ONE
  325. Eun (2013), The Igf2/H19 muscle enhancer is an active transcriptional complex., Nucleic Acids Res.
  326. Ge (2013), HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway., Cancer Sci.
  327. Hajjari (2013), Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues., Med. Oncol.
  328. Hangauer (2013), Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs., PLoS Genet.
  329. Holdt (2013), Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks., PLoS Genet.
  330. Ishibashi (2013), Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma., Oncol. Rep.
  331. Jalali (2013), Systematic transcriptome wide analysis of lncRNA-miRNA interactions., PLoS ONE
  332. Juan (2013), Potential roles of microRNAs in regulating long intergenic noncoding RNAs., BMC Med Genomics
  333. Kim (2013), HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer., Oncogene
  334. Lai (2013), Activating RNAs associate with Mediator to enhance chromatin architecture and transcription., Nature
  335. Li (2013), Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma., Am. J. Pathol.
  336. Li (2013), Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma., Br. J. Cancer
  337. Li (2013), Targeted disruption of Hotair leads to homeotic transformation and gene derepression., Cell Rep
  338. Li (2013), Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer., J. Exp. Clin. Cancer Res.
  339. Ling (2013), MicroRNAs and other non-coding RNAs as targets for anticancer drug development., Nat Rev Drug Discov
  340. Liu (2013), Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6., PLoS ONE
  341. Liu (2013), The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer., BMC Cancer
  342. Liu (2013), The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression., PLoS ONE
  343. Lu (2013), Computational prediction of associations between long non-coding RNAs and proteins., BMC Genomics
  344. Lu (2013), Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression., BMC Cancer
  345. Luco (2013), The non-coding genome: a universe in expansion for fine-tuning the coding world., Genome Biol.
  346. Luo (2013), Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression., FEBS J.
  347. Lv (2013), Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival., PLoS ONE
  348. Mudge (2013), Functional transcriptomics in the post-ENCODE era., Genome Res.
  349. Nakagawa (2013), Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer., Biochem. Biophys. Res. Commun.
  350. Nie (2013), Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival., Cancer Sci.
  351. Niemczyk (2013), Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA., Am. J. Hum. Genet.
  352. Papait (2013), Long noncoding RNA: a new player of heart failure?, J Cardiovasc Transl Res
  353. Prensner (2013), The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex., Nat. Genet.
  354. Pádua Alves (2013), Brief report: The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines., Stem Cells
  355. Qi (2013), Low expression of LOC285194 is associated with poor prognosis in colorectal cancer., J Transl Med
  356. Qiu (2013), Long noncoding RNA: an emerging paradigm of cancer research., Tumour Biol.
  357. Rapicavoli (2013), A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics., Elife
  358. Redis (2013), CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations., Oncotarget
  359. Sánchez (2013), Long non-coding RNAs: challenges for diagnosis and therapies., Nucleic Acid Ther
  360. Sørensen (2013), Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer., Breast Cancer Res. Treat.
  361. Takayama (2013), Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer., EMBO J.
  362. Tang (2013), Long noncoding RNAs-related diseases, cancers, and drugs., ScientificWorldJournal
  363. Tang (2013), Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma., Biomed Res Int
  364. Vallot (2013), Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome., RNA Biol
  365. Venkatesh (2013), Non-coding transcription SETs up regulation., Cell Res.
  366. Volders (2013), LNCipedia: a database for annotated human lncRNA transcript sequences and structures., Nucleic Acids Res.
  367. Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
  368. Wang (2013), EZH2 takes the stage when BRCA1 loses., Cell Cycle
  369. Wu (2013), Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma., Gastroenterology
  370. Wu (2013), A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations., Carcinogenesis
  371. Wu (2013), Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells., PLoS ONE
  372. Wu (2013), Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins., Biochemistry
  373. Xu (2013), Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer., Int. J. Biol. Sci.
  374. Yoon (2013), Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination., Nat Commun
  375. Zhang (2013), Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis., Asian Pac. J. Cancer Prev.
  376. Zhang (2013), HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma., Neuro-oncology
  377. Zhao (2013), HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells., J. Cell. Biochem.
  378. Zhuang (2013), Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen., J Hematol Oncol
  379. Zou (2013), Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo., PLoS ONE
  380. Özgür (2013), Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells., Clin. Exp. Med.
  381. Augoff (2012), miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer., Mol. Cancer
  382. Brunner (2012), Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers., Genome Biol.
  383. Bánfai (2012), Long noncoding RNAs are rarely translated in two human cell lines., Genome Res.
  384. Chisholm (2012), Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma., PLoS ONE
  385. Chu (2012), Chromatin isolation by RNA purification (ChIRP)., J Vis Exp
  386. Du (2012), Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18., J. Biol. Chem.
  387. Flockhart (2012), BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration., Genome Res.
  388. Glazko (2012), Computational prediction of polycomb-associated long non-coding RNAs., PLoS ONE
  389. Gong (2012), Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes., Methods
  390. Jeggari (2012), miRcode: a map of putative microRNA target sites in the long non-coding transcriptome., Bioinformatics
  391. Kelley (2012), Transposable elements reveal a stem cell-specific class of long noncoding RNAs., Genome Biol.
  392. Li (2012), AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans., Proc. Natl. Acad. Sci. U.S.A.
  393. Lu (2012), Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer., Breast Cancer Res. Treat.
  394. Maruyama (2012), Altered antisense-to-sense transcript ratios in breast cancer., Proc. Natl. Acad. Sci. U.S.A.
  395. Mizutani (2012), Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells., PLoS ONE
  396. Nagy (2012), [Relevance of long non-coding RNAs in tumour biology]., Orv Hetil
  397. Nakagawa (2012), Malat1 is not an essential component of nuclear speckles in mice., RNA
  398. Nam (2012), Long noncoding RNAs in C. elegans., Genome Res.
  399. Ng (2012), Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors., EMBO J.
  400. Niazi (2012), Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3' UTRs., RNA
  401. Niinuma (2012), Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors., Cancer Res.
  402. Ren (2012), RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings., Cell Res.
  403. Sati (2012), Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci., Nucleic Acids Res.
  404. Talkowski (2012), Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities., Am. J. Hum. Genet.
  405. Tani (2012), Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals., Genome Res.
  406. Troy (2012), Genetic "lnc"-age of noncoding RNAs to human disease., J. Clin. Invest.
  407. Vizoso (2012), The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy., Cell Res.
  408. Wilusz (2012), HuR and translation--the missing linc(RNA)., Mol. Cell
  409. Bright (2011), Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum., BMC Biol.
  410. Chan (2011), Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection., PLoS ONE
  411. Chu (2011), Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions., Mol. Cell
  412. Derrien (2011), [Long non-coding RNAs with enhancer-like function in human cells]., Med Sci (Paris)
  413. He (2011), The sequence, structure and evolutionary features of HOTAIR in mammals., BMC Evol. Biol.
  414. Kogo (2011), Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers., Cancer Res.
  415. Kotake (2011), Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene., Oncogene
  416. Milhem (2011), Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients., J Cancer Sci Ther
  417. Nakagawa (2011), eXIST with matrix-associated proteins., Trends Cell Biol.
  418. Paralkar (2011), A new 'Linc' between noncoding RNAs and blood development., Genes Dev.
  419. Rose (2011), Molecular evolution of the non-coding eosinophil granule ontogeny transcript., Front Genet
  420. Saxena (2011), Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs., Bioessays
  421. Schorderet (2011), Structural and functional differences in the long non-coding RNA hotair in mouse and human., PLoS Genet.
  422. Simon (2011), The genomic binding sites of a noncoding RNA., Proc. Natl. Acad. Sci. U.S.A.
  423. Tahira (2011), Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer., Mol. Cancer
  424. Wang (2011), Molecular mechanisms of long noncoding RNAs., Mol. Cell
  425. Xin (2011), Identification and characterization of wheat long non-protein coding RNAs responsive to powdery mildew infection and heat stress by using microarray analysis and SBS sequencing., BMC Plant Biol.
  426. Yang (2011), Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation., Ann. Surg. Oncol.
  427. Zong (2011), RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs., RNA Biol
  428. Gupta (2010), Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis., Nature
  429. Tsai (2010), Long noncoding RNA as modular scaffold of histone modification complexes., Science
  430. Khalil (2009), Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression., Proc. Natl. Acad. Sci. U.S.A.
  431. Rinn (2007), Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs., Cell
  432. Woo (2007), HOTAIR lifts noncoding RNAs to new levels., Cell


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
3.1 lnc-SMUG1-7:7
4.0 HOTAIR:5
4.1 HOTAIR:5
5.0 HOTAIR:5
5.1 HOTAIR:5
5.2 HOTAIR:5